Fresh vs. Frozen MSC Stem Cells: Understanding the Superiority of Fresh Cells
We know that Mesenchymal Stem Cells (MSCs) have emerged as a powerful tool for treating various medical conditions, ranging from orthopedic injuries to autoimmune diseases. These multipotent cells have the remarkable ability to differentiate into different cell types and promote tissue repair and regeneration. However, the debate between fresh and frozen MSC stem cells has been ongoing. In this blog post, we’ll delve into the reasons why fresh MSC stem cells are considered superior to their frozen counterparts.
1. Viability and Potency:
One of the primary differences between fresh and frozen MSC stem cells lies in their viability and potency. Fresh MSCs are harvested and used within 72 hours after extraction, meaning they are at their peak state of activity. This immediate use ensures that the cells retain maximum viability and potency, as they have not undergone the potentially damaging effects of cryopreservation.
Frozen MSC stem cells, on the other hand, are preserved using cryopreservation techniques. While cryopreservation allows for long-term storage and transportation of cells, it also leads to a decrease in viability and potency of at least 50% and often the loss of even more viable cells. The freezing and thawing process can cause cellular damage, resulting in reduced effectiveness once the cells are introduced into the body.
2. Clinical Outcomes:
Numerous studies have compared the clinical outcomes of treatments using fresh and frozen MSC stem cells. In general, fresh MSCs have been shown to yield better results for patients. For example, a study published in the journal Stem Cells Translational Medicine found that patients treated with fresh MSCs for osteoarthritis experienced greater improvements in pain and function compared to those treated with frozen MSCs.
Another study, published in the Journal of Orthopaedic Research, investigated the use of fresh and frozen MSCs for rotator cuff repair. The study found that patients treated with fresh MSCs had better tendon healing and improved functional outcomes compared to those treated with frozen MSCs.
3. Inflammatory Response:
Fresh MSC stem cells have been shown to exhibit reduced inflammatory responses compared to frozen cells. This is important, as excessive inflammation can hinder the healing process and lead to complications. By using fresh MSCs, clinicians can potentially mitigate the inflammatory response and promote more effective tissue repair.
4. Ease of Use:
Fresh MSC stem cells offer the advantage of immediate availability, making them easier to use in clinical settings. Clinicians can harvest the cells and use them in procedures without the need for extensive processing or thawing. This convenience can streamline treatment protocols and reduce the time required for patient care.
In contrast, frozen MSCs require thawing and preparation before they can be used, adding an extra step to the treatment process. This additional processing time can delay treatment and may impact the viability and potency of the cells.
Ophelia Rises is focused on you and the working for the best results and outcomes so we exclusively use fresh stem cells from fully certified labs. Want to learn more? Let’s get in touch today.
